H. Winter Griffith, M.D.
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 In large doses, decreases cholesterol production.
Time lapse before drug works:
15 to 20 minutes.
Don't take with:
Any other medicine without consulting your doctor or pharmacist.
0
POSSIBLE
ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS
WHAT TO DO
Life-threatening:
None expected.
Common:
Dry skin.
Continue. Call doctor when convenient.
Infrequent:
• Upper abdominal pain, diarrhea.
• Headache, dizziness, faintness, temporary numbness and tingling in hands and feet.
• "Hot" feeling, flush.
Discontinue. Call doctor right away. Continue. Call doctor when convenient. |
F. Batmanghelidj
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 In 1987, at an international gathering of cancer research scientists in Greece, I exposed the scientific reasons why increased cholesterol production in the body is a direct consequence of chronic dehydration.
We have to assume that the genetic structure of each cell empowers it to act independently, if environmental conditions are not to its advantage. The cells of the human body have the same capability as bacteria to adapt to their environment by altering their membrane structure. |
Linda B. White, M.D.
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 It actually inhibits cholesterol production, a feature that makes this form a good choice for people whose bodies make higher than normal amounts of LDL cholesterol, despite changes in diet. Typical dosage: 25 to 100 milligrams per day.
ž Vitamin B6. Deficiency of this key B vitamin appears to be a major cause of heart disease. It can be taken as part of a good quality multivitamin or a B-complex combination. Typical dosage: 25 to 50 milligrams of B6 per day.
ž Magnesium. |
| One form of this vitamin inhibits the body's cholesterol production. Typical dosage: 25 to 100 milligrams of the tocotrienol form per day.
ž Magnesium. It may help decrease plaque formation. Typical dosage: 500 to 1,000 milligrams per day. Caution: If diarrhea occurs, reduce the dose.
ž Niacin. It lowers cholesterol. Take the niacin precursor inositol hexa-niacinate; it doesn't produce niacin's usual side effects, such as flushing and liver damage. Typical dosage: 50 to 100 milligrams three times per day.
ž L-carnitine. Among other benefits, this supplement prevents plaque formation. |
Neal Barnard, M.D.
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 In addition, fiber may actually cause the liver to turn down its cholesterol production.34
In spite of what television commercials might suggest, oat bran is only one of many good sources of soluble fiber. Beans also contain soluble fiber. If beans had a lobby group as strong as the dairy or meat industries, everyone would know that beans are not only calcium-rich, zero-cholesterol, extremely low-fat protein powerhouses, and a good source of omega-3 fatty acids but also contain lots of soluble fiber. |
Grace Ross Lewis
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 These are antioxidants that protect against cancer and prevent cholesterol production.
70. Is there any way to avoid the danger of salmonella when eating raw eggs or foods that contain raw eggs like Caesar salad?
Food scientists at Purdue University have figured out a way to pasteurize eggs in their shells. Currently, the only safe ones would be the liquid ones that have been removed from their shells and pasteurized.
71. Are there any natural food preservatives or are they always in the form of added chemicals?
There are naturally occurring food preservatives. |
Phyllis A. Balch, CNC
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 Soy lecithin's ability to reduce cholesterol production helps to prevent the formation of gallstones because most gallstones are composed mostly of cholesterol.
• Hangover. Soy lecithin not only helps protect the liver against the effects of alcohol, but helps to ease hangover symptoms. It fights fatigue and hypoglycemia, or low blood sugar, by stopping free-radical activity that would desensitize liver cells to low blood-sugar levels. In addition, soy lecithin ensures that the liver releases glucose to cover skipped meals.
• Multiple sclerosis (MS). |
| Other drugs reduce cholesterol production within the liver itself. All these medications have possible side effects, ranging from digestive upsets to liver disturbances.
Ll People who have both high cholesterol and high triglycerides may benefit from supplementation with pan-tethine, the active form of vitamin B5. In one clinical trial, a dosage of 900 milligrams per day lowered triglyceride levels by over 30 percent, total cholesterol levels by nearly 20 percent, and LDL levels by over 20 percent, all while raising HDL levels by nearly 25 percent. |
Jean Carper
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 Other foods create different chemicals that seem to also turn down internal cholesterol production. Further, that is precisely how the potent cholesterol-reducing drug Mevacor (lovas-tatin) also works.
On the other hand, some foods, such as oats, are thought to deplete supplies of bile acids in the intestinal tract that otherwise would be turned into cholesterol.
Along new and more exciting lines, food antioxidants may help keep bad-type LDL cholesterol from becoming oxidized and toxic to arteries. Here are three possible ways food antioxidants may work, according to Harvard's Dr. Balz Frei. |
Earl L. Mindell, R.Ph., Ph.D.
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 But perhaps even more serious than the above side effects is the fact that the same mechanism that blocks cholesterol production also blocks the production of coenzyme Q10, a substance essential to a healthy heart and muscles. Your physician may tell you that you'll never have a shortage of CoQIO, but this is not borne out by the facts. The truth is that heart disease patients are consistently found to have low levels of coenzyme Q10. |
Stephen T., M.D. Sinatra
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 For example, if we do not get enough of two EFAs called linoleic acid and linolenic acid, our bodies may produce an abnormal fatty acid called mead fatty acid, which can cause additional cholesterol production and ultimately lead to hardening of the arteries.
While most cardiologists recommend a low-fat diet for the prevention or reduction of coronary artery disease, they may overlook the substantial evidence we now have concerning the link between low linolenic/linoleic fatty acid intake and coronary artery disease.
We must not be too overzealous in our approach to fats. |
Mary G. Enig
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 Some reasons are related to genetics, and some are related to things like increased cholesterol production in response to increased stress. (See Chapters 1 and 2 for more details)
What About Fat and Heart Disease?
The claim that saturated fat leads to heart disease is simply false. This claim was initiated as a marketing tool to sell oils and margarine (in competition to butter, lard and tallow). Eventually the idea became dogma as it was repeated year after year. The major fatty acids in the cholesterol esters in the atheroma blockages are unsaturated (74 percent of total fatty acids). |
Gary Null, Ph.D.
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 Despite the low vitamin count in pearled barley, a substance known to inhibit cholesterol production in the blood has been found in the nonfibrous portion of the grain. To cook, use 3 cups water to 1 cup pearl barley. Cook for thirty-five to forty-five minutes. To cut cooking time, presoak grain at least five hours and cook for fifteen minutes. Hulled barley must be soaked overnight and requires one hour cooking time. Cook covered; add liquid as required. Hulled kernels can be sprouted for salads.
Bran This isn't a kind of grain. |
Larry Trivieri, Jr.
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 Prominent among these substantiated claims is garlic's ability to lower blood pressure, inhibit cholesterol production and reduce triglyceride levels, promote blood circulation, and discourage clot formation.Yu-YanYeh, Ph.D. |
Robert S. McCaleb, Evelyn Leigh, and Krista Morien
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 Higher doses of garlic hindered cholesterol production both at early and later stages.42 Garlic may also enhance excretion of sterols and bile acids, as was demonstrated in an animal study comparing the cholesterol-lowering effects of S-allyl-cysteine with guggulipid.43 Allicin, ajoene, adenosine, and a number of other compounds are believed to be important in garlic's lipid-lowering action.3'15'41
Effects on Blood Pressure
Garlic's precise mode of action in lowering blood pressure is not clear. |
| There is evidence that whole artichoke extract indirectly affects cholesterol production in at least two ways, both by interfering with processes that activate cholesterol synthesis and by activating mechanisms that inhibit cholesterol synthesis.4
In studies investigating antioxidant effects in cultured liver cells, artichoke extract protected cells from damage in part by preventing loss of glutathione, a naturally occurring antioxidant that plays an essential role in neutralizing toxins.14'15 If enough glutathione is lost, liver damage results. |
Natural Prescriptions: Dr. Giller's Natural Treatments & Vitamin Therapies For Over 100 Common AilmentsRobert M. Giller, M.D.
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| Be sure if you take lysine supplements that you watch your cholesterol levels, as there's some evidence that lysine may stimulate the liver to increase cholesterol production.
In addition to taking lysine as a supplement, it can be applied topically in the form of lysine cream, available in health food stores. I usually advise applying it topically twice a day, but check the directions on the label.
Since cold sores are stimulated by the imbalance of the amino acids arginine and lysine, it can also be beneficial to avoid arginine-containing foods. |
David Heber, M.D., Ph.D.
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 They have a very sensitive system for adjusting cholesterol production in the body in response to increased cholesterol intake.
I recently met a brilliant scientist at a conference and I invited him to my office, thinking I could help him improve his health. He was in his mid-thirties and overweight by forty or so pounds, and I had noticed at dinner during the conference that he indulged in high-fat meat and dessert. My plan was to help him lower his undoubtedly high cholesterol levels and shed some of the extra weight he carried around. |
Earl L. Mindell, R.Ph., Ph.D.
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| In one study, ingesting this amount daily brought a 26 percent reduction in LDL or "bad" cholesterol production.
Psyllium: 1 to 2 teaspoons a day. Be sure to drink eight glasses of water a day too.
N-acetyl cysteine (NAC): 500 mg three times a day. This will help raise your glutathione levels, which will support your liver so it can more efficiently excrete cholesterol. |
Neal Barnard, M.D.
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 Barley is an excellent source of protein and fiber, and scientists have also discovered that certain substances in barley, in addition to soluble fiber, inhibit cholesterol production. Hulled barley is sold in natural food stores and is significantly more nutritious than the more familiar pearled barley.
1 cup hulled or pearled barley* 3 cups water % teaspoon salt
In a medium-size saucepan, combine all ingredients. Cover and bring to a simmer over medium heat. Continue cooking, stirring occasionally, for about 30 minutes, until the barley is tender (it will still be slightly chewy). |
Sheldon Saul Hendler and David Rorvik
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 Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hdroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1993; 268:11230-11238. rearce bc, rancer ka, ueason ivih, et ai. mmoiiors 01 cholesterol biosynthesis. 2. Hypocholesterolemic and antioxidant activities of benzopyran and tertrahydronaphthalene analogues of the tocotrienols. J Med Chem. 1994; 37:526-541.
Quereshi AA, Bradlow BA, Manganello J, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids. 1995; 30:1171-1177.
Quereshi AA, Pearce BC. |
James A. Howenstine, MD
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 The effective statin cholesterol lowering drugs act by filling receptor sites that receive the cholesterol production stimulating enzyme HMG-CoA reductase. When this does not land on the receptor site the level of cholesterol in the blood falls. To overcome this blockage the body secretes great and greater quantities of HMG-CoA reductase, as much as 200 times the normal. Some authorities believe this excessive production of HMG-Co reductase may be the cause for liver injury that can occur with statin therapy. |
David Heber, M.D., Ph.D.
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| Some genetic endowment from his
Scandinavian heritage had geared his cells to downregulate cholesterol production quite efficiently when he ate high-cholesterol foods.
Statin Drugs and Red Yeast Rice
Statin drugs such as lovastatin are the most commonly prescribed medications for high cholesterol. They work by blocking an enzyme needed to make cholesterol in the body. They also act to stabilize cholesterol deposits in the blood-vessel wall, decreasing the likelihood that they will burst open and cause clots to form. |
| Cholesterol, a key molecule in so many body processes, is one of the most carefully regulated through control of both cholesterol production and excretion from the body.
Cholesterol has many uses in the body. It is the stuff from which the hormones Cortisol, progesterone, testosterone, and estrogen are built. It is a structural component of the membranes of cells, and it is needed for the production of bone-building vitamin D.
Plants contain no cholesterol. Many plant foods (e.g., beans) contain chemicals called "phytosterols," which block the absorption of cholesterol in the gut. |
Phyllis A. Balch, CNC
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| Reduces cholesterol production in the liver.
Turmeric
Curcumin tablets. Take 125 mg 3 times daily.
Inhibits formation of cholesterol crystals.
Precautions for the use of herbs:
1 Peppermint should be used only during mild spasms. Do not use it when symptoms are absent, because it may slow the normal passage of bile. 2Do not take prickly ash internally.
3Boldo, greater celandine, milk thistle, and soy lecithin can cause mild diarrhea. 4Do not use gentian if you have diarrhea.
HERBS TO AVOID
Q Individuals who have gallstones should avoid gardenia and schisandra. |
Bill Gottlieb
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 Imagine talking to the supervisor of cholesterol production and suggesting that production quotas should be lower, so less cholesterol is made. He agrees and promises that your cholesterol will be maintained at a lower, healthy level.
Dossey recommends doing this exercise twice a day, 15 to 20 minutes each session.
Reflexology
To help your body rid itself of cholesterol more efficiently, St. Petersburg, Florida, reflexologist Dwight Byers, author of Better Health with Foot Reflexology, says you should work the thyroid gland and liver reflexes on your hands or feet. |
Ronald L. Hoffman, M.D.
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 It's theorized that the water-soluble fibers may help build up that fatty acids that inhibit cholesterol production by the liver. They may also increase the excretion of bile from the intestine, preventing the recycling of cholesterol components back into the body. In one study, men with a high cholesterol level (over 250) ate 100 grams or more a day of fiber in the form of hot oatmeal cereal, muffins, or beans and showed a significant reduction in both total cholesterol level and in LDL levels. This quantity of fiber is far above the current health guidelines of only 20 to 35 grams a day. |
Ruth Winter
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 Have been found to inhibit cholesterol production and aid protective enzyme activity.
MONOUNSAT FAT • The listing on food labels for monounsaturated fat (see). MONOUNSATURATED FATS • The saturation of fat refers to the chemical structure of its fatty acids. Saturated fats, which are hard at room temperature— lard, suet, and butter fat are examples—consist primarily of fatty acids that contain a full load of hydrogen atoms. Monounsaturated fatty acids, however, can accept two additional hydrogen atoms. |
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